South Carolina Upstate Spartans vs South Carolina State Bulldogs
| Team | 1H | 2H | T |
|---|---|---|---|
 UPST | 35 | 47 | 82 |
 SCST | 32 | 46 | 78 |
Who won: SC Upstate 82-78
The South Carolina Upstate Spartans beat the South Carolina State Bulldogs 82-78 on Tuesday, November 23, 2021 at Smith-Hammond-Middleton Memorial Center. Ahmir Langlais led the SC Upstate in points (15). Edward Oliver-Hampton led the SC State in points (19).
UPST
Vermont4-258
Evansville2-549Final- Covenant39
Chattanooga5-0100Final 
Wright St1-476
James Madison5-178Final
Southern Utah2-388
Yale3-385Final/OT
MTSU4-160
Rider2-454Final
App State3-357
Akron2-345Final
Penn3-561
Towson3-276Final
Texas A&M5-157
Butler3-350Final
Drexel3-267
Charlotte3-255Final
Long Beach St1-443
Murray St4-180Final