Houston Astros vs St. Louis Cardinals
| Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R |
|---|---|---|---|---|---|---|---|---|---|---|
 HOU | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 |
 STL | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | X | 4 |
Who won: Cardinals 4-2
The St. Louis Cardinals beat the Houston Astros 4-2 on Friday, March 18, 2022 at Roger Dean Chevrolet Stadium. The Cardinals lead the series 1-0. The Cardinals outscored the Astros 2-0 in the 3rd inning. Andrew Knizner went 1-for-1 with a home run and 2 RBI for the Cardinals.
