NFL · Head to head
Colts vs 49ers
The 49ers won their only meeting with the Colts, by an average of 21 points. Last meeting: 49ers 48, Colts 27 on Dec 21, 2025.
IND record
0-1
Last 5
0-1
IND points
27.0
SF points
48.0
Every meeting
| Date | Result | Top performers |
|---|---|---|
| Dec 21, 2025vs SF | L 27-48 |
Colts players in this matchup
49ers players in this matchup