Houston Astros vs Chicago Cubs

MLB

Astros

21-31

4-2

Final

Cubs

29-22

Wrigley Field

TV: MLB.TV

Team	1	2	3	4	5	6	7	8	9	R
HOU	0	0	1	2	1	0	0	0	0	4
CHC	0	0	0	0	0	2	0	0	0	2

Who won: Astros 4-2

The Houston Astros beat the Chicago Cubs 4-2 on Friday, May 22, 2026 at Wrigley Field. The Astros win the series 3-0. The Astros outscored the Cubs 2-0 in the 4th inning. Christian Vazquez went 2-for-4 with a home run and 2 RBI for the Astros. Pete Crow-Armstrong went 1-for-2 with a home run and 2 RBI for the Cubs.

Recap · May 22

Astros extend Cubs' skid to 6 with 4-2 victory

Christian Vazquez homered, Spencer Arrighetti threw five scoreless innings and the Houston Astros topped the scuffling Chicago Cubs 4-2 on Friday.

What it means

Season series: HOU wins series 3-0.
Cubs have lost 5 straight.
Astros 9-17 on the road; Cubs 18-9 at home.

Latest headlines

ESPN · 3d ago

Inside a Wrigleyville rooftop owner's fight with the Cubs

ESPN · 3d ago

Inside a Wrigleyville rooftop owner's fight with the Cubs

ESPN · Oct 2

Cubs' Jed Hoyer makes 'pitching acquisition' top offseason priority

ESPN · Oct 1

Astros manager Joe Espada wants to return as contract expires

ESPN · Oct 1

Padres silence Cubs' bats again, finish off 2-game wild-card sweep

ESPN · Oct 1

Wrigley Field rooftop business can't sell tickets to Cubs games

Recap · Oct 1

White Sox pounce early, finish sweep of Astros for first playoff series win since 2005

Recap · Oct 1

Gavin Sheets' pinch-hit homer propels dominant Padres past Cubs 4-1 for 2-game Wild Card sweep

Injuries and inactives

Astros1st in AL West

Brice Matthews CF
Knee, Inflammation, left
Out
Cristian Javier SP
Groin, Strain, right
Out
Daulton Varsho CF
Wrist, Surgery, left
Out
Enyel De Los Santos RP
Knee, Tendinitis, right
Out
Mike Burrows SP
Elbow, Inflammation, right
60-Day-IL

Cubs2nd in NL Cent

Ben Brown RP
Neck, Fracture
60-Day-IL
Justin Steele SP
Elbow, Surgery, left
60-Day-IL
Phil Maton RP
Knee, Sprain, right
60-Day-IL
Riley Martin RP
Elbow, Strain, left
60-Day-IL
Shelby Miller RP
Elbow, Surgery, right
60-Day-IL

Probable starters

Astros1st in AL West

Spencer Arrighetti SP

Probable starter · 9-9, 4.96 ERA, 106 K, 1.38 WHIP

Lineup

1Jeremy PenaSS
2Isaac Paredes3B
3Yordan AlvarezDH
4Christian Walker1B
5Jake MeyersCF
6Braden Shewmake2B
7Cam SmithRF
8Zach ColeLF
9Christian VazquezC

Cubs2nd in NL Cent

Jameson Taillon SP

Probable starter · 2-6, 5.65 ERA, 76 K, 1.36 WHIP

Lineup

1Nico Hoerner2B
2Michael Busch1B
3Alex Bregman3B
4Ian HappLF
5Seiya SuzukiRF
6Michael ConfortoDH
7Carson KellyC
8Pete Crow-ArmstrongCF
9Dansby SwansonSS

The series

HOU wins series 3-0

Last 5

HOU

W@ CHC4-2
L@ MIN1-4
W@ MIN2-1
L@ MIN3-6
Lvs TEX0-8

CHC

Lvs HOU2-4
Lvs MIL0-5
Lvs MIL2-5
Lvs MIL3-9
L@ CHW8-9

Chirp's angle

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Game info

Venue: Wrigley Field, Chicago, Illinois · Attendance 37,332
Officials: Chad Fairchild (Home Plate Umpire), Chad Whitson (First Base Umpire), Bill Miller (Second Base Umpire), Brian Walsh (Third Base Umpire)